- VASCULAR GROWTH IN Tumor
angiogenesis : A MATHEMATICAL MODEL IN
three dimensions, Rita
Coimbra2, Maurício Moreira-Soares1,2,3, João
Carvalho1,2, Rui Travasso1,2
1 Departamento de Física da
Universidade de Coimbra.
2 Centro de Física da Universidade de Coimbra
(CfisUC).
3 Instituto de Física e Matemática,
Universidade Federal de Pelotas, Pelotas.
E-mail de contacto: rita@teor.fis.uc.pt
Abstract:
Cancer is among the leading
causes of death worldwide1. Sprouting
angiogenesis, the process during which new
blood vessels grow from existing ones, is
crucial in growth of solid tumors. In response
to a chemotactic stimulus (Vascular
Endothelial Growth Factor), each endothelial
cell of the vessel sprout can adopt either a
migratory or a proliferating phenotype. In
this work we use the multi-scale phase field
model of vesssel growth in 3D coupled with
hydrodynamics of blood flow2,3 and we discuss
the role of the endothelial cells' chemotactic
response and proliferation rate as key factors
in determining the morphology of vascular
networks.
[1] World Cancer Report 2014
[2] Rui D. M. Travasso, Eugenia Corvera Poiré,
Mario Castro, Juan Carlos Rodríguez-Manzaneque,
A. Hernández-Machado, PLoS ONE 6, e19989 (2011).
[3] M. Moreira, Coupling blood flow and growing
vasculature in three dimensions, Dissertation
(Master Degree in Physics), Instituto de Física
e Matemática, Universidade Federal de Pelotas,
Pelotas, 2015.
- Cardio-renal syndrome: a clinical case
Cachapuz I1, Pinto C2, Oliveira A3
1Unidade Local de Saúde de Matosinhos –
ULSM, E.P.E.
Serviço de Patologia Clínica
2Instituto Superior de Engenharia do Porto,
Centro de Matemática da Universidade do Porto
3Escola Superior das Tecnologias da Saúde
Keywords: Cardio-renal syndrome, creatinine.
Introduction: The cardio-renal syndromes (SCR)
are disorders of the heart and kidney in which
an acute or chronic dysfunction in one organ
can induce an acute or chronic impairment in
the other. Acute SCR affects 27%- 40% of
patients hospitalized for decompensated heart
failure. The increase in creatinine values on
admission or during hospitalization is
independently associated with increased
mortality, longer hospital stays and higher
number of re-admissions. Acute kidney injury
(AKI) is not only the most serious marker, but
acts accelerating cardiovascular injury.
- Evaluation of the External Quality
Control for Therapeutic Drugs
Cachapuz I1, Pinto C2, Oliveira A3
1Unidade Local de Saúde de Matosinhos –
ULSM, E.P.E.
Serviço de Patologia Clínica
2Instituto Superior de Engenharia do Porto,
Centro de Matemática da Universidade do Porto
3Escola Superior das Tecnologias da Saúde
Keywords: Acetaminophen, Carbamazepine,
Digoxin, Gentamicin, Quality Control.
Introduction: The participation in recognized
external quality assessment programs is a key
element in ensuring the quality of the results
provided by the Clinical Pathology Laboratory.
The monitoring of therapeutic drugs requires
special care by the narrow therapeutic margin
that several drugs commonly used in clinical
practice have.
- Proteinuria in Matosinhos Local Health
Unit: Patients of 2015
Cachapuz I1, Carvalho A2, Pinto C3, Pereira
A4
1,4Unidade Local de Saúde de Matosinhos –
ULSM, E.P.E.
Serviço de Patologia Clínica
2Faculdade de Ciências da Universidade do
Porto
3Instituto Superior de Engenharia do Porto,
Centro de Matemática da Universidade do Porto
Keywords: Proteinuria, chronic kidney disease,
measurement
Introduction: Proteinuria is a common finding
in adults in primary care practice. Benign
causes include fever, intense activity or
exercise, dehydration, emotional stress and
acute illness. More serious causes include
glomerulonephritis and multiple myeloma.
Determination of urinary excretion of total
protein is the most sensitive and relevant
examination, the day -to-day practice, for
early detection of chronic kidney disease
(CKD), a condition whose prevalence has
increased. Twenty-four–hour urine collection
is the most accurate test for quantification
of proteinuria. However, the test becomes
inaccurate when difficulties with urine
collection are encountered. To minimize
collection and handling errors, patients
should receive detailed instructions about
24-hour urine collection.
- Analysis of Laboratory Critical Value
Reporting at Matosinhos Local Health Unit
Cachapuz I1, Oliveira A2, Pinto C3, Carvalho
A4, Pereira A5, Fonseca R6
1,5,6Unidade Local de Saúde de Matosinhos –
ULSM, E.P.E.
Serviço de Patologia Clínica
2Escola Superior de Tecnologias da Saúde
3Instituto Superior de Engenharia do Porto,
Centro de Matemática da Universidade do Porto
4Faculdade de Ciências da Universidade do
Porto
Keywords: Critical Value, Reporting, Time
Introduction: Lundberg defined "critical
value" (CV) as an extremely abnormal result,
requiring therefore an urgent action.
According to the national goals of the Joint
Commission, the communication of CV of tests
or diagnostic procedures must occur in a time
interval such as to provide proper treatment
of the patient. The CV may be quantitative,
semi-quantitative or qualitative. Campbell and
Horvath (2012) consider that a CV is one that
requires fast communication, because there is
a life threatening condition for the patient.
- Comparison between MDRD4 and CKD-EPI in
Primary Health Care of Matosinhos Local
Health Unit
Cachapuz I1, Carvalho A3, Pinto C5,
Oliveira A6, Pereira A4
1,2,4Unidade Local de Saúde de Matosinhos
– ULSM, E.P.E.
Serviço de Patologia Clínica
3Faculdade de Ciências da Universidade do
Porto
5Instituto Superior de Engenharia do Porto,
Centro de Matemática da Universidade do Porto
6Escola Superior de Tecnologias da Saúde
Keywords: Glomerular Filtration Rate,
Modification of Diet in Renal Disease
equation, The Chronic Kidney Disease
(CKD)-Epidemiology Collaboration (CKD-EPI)
Equation
Introduction: Chronic kidney disease (CKD) is
considered a public health problem worldwide.
It has beem frequently associated to the aging
of the population and the increase in risk
factors such as hypertension, diabetes and
obesity.
CKD is defined by the presence of parenchymal
renal damage markers or Glomerular Filtration
Rate (GFR) FG <60mL / min / 1.73m2 for 3
months or more and is divided into 5 stages.
GFR can be calculated using equations such as
the Cockcroft-Gault, the Modification of Diet
in Renal Disease equation (MDRD) and The
Chronic Kidney Disease Epidemiology
Collaboration (CKD-EPI) equation. The CKD-EPI
equation is newer and offers more reliable
results that the equations used previously.
The CKD has Stages - I:> = 90; II: 60-89;
III: 30-59; IV: 15-29; V: <15.
The CKD-EPI uses the same variables as the
MDRD4, but comparatively shows better
performance and risk prediction. CKD-EPI has
less biased, especially for GFR> 60mL / min
/ 1.73m2.