A Calabi-Yau orbifold is locally modeled on C^n/G with G a finite subgroup of SU(n). If the singularity is isolated, then the crepant resolution (if it exists) is an ALE manifold, for which index-type results are well known. However, most of the time the singularity is not isolated, and for the corresponding crepant resolution there is no index theorem so far. In this talk, I present the first step towards obtaining such a result: I will introduce the class of iterated cone-edge singular manifolds and the corresponding quasi-asymptotically conical spaces (for which orbifolds and their crepant resolutions are an example), and build-up the general set-up for studying Fredholm properties of geometrical elliptic operators on these spaces. This is joint work with Rafe Mazzeo.