In recent years, mathematical modeling of cardiovascular drug delivery systems has become an efective tool to gain deeper insights in the cardiovascular diseases like atherosclerosis. In the case of the coronary biodegradable stent, it leads to a deeper understanding of drug release mechanisms from polymeric stent into the arterial wall. In this talk, a two-dimensional coupled nonlinear non-Fickian model for drug release from a biodegradable drug-eluting stent into the arterial wall is presented. The influence of porosity and degradation of the polymer as well as the dissolution rate of the drug are analyzed. Numerical simulations that illustrate the kind of dependence of drug profiles on these properties are included.